PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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13-Hydroxytridecanoic acid
0 ImagesCat. No.: HY-W410756CAS No.: 7735-38-8
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Cyclobutane-1,3-dicarboxylic acid
0 ImagesCat. No.: HY-W062484CAS No.: 62184-63-8
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Propargyl-PEG3-NH-Boc
0 ImagesCat. No.: HY-W855790CAS No.: 2222039-38-3
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3-(2-Aminoethoxy)propan-1-ol hydrochloride
0 ImagesCat. No.: HY-24586CAS No.: 947664-36-0
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Boc-pyrrolidine-Pip-C2-NH2
0 ImagesCat. No.: HY-W383171CAS No.: 1420809-96-6
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Boc-NH-C3-O-Propargyl
0 ImagesCat. No.: HY-W923498CAS No.: 1187357-11-4
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Methyl 17-bromoheptadecanoate
0 ImagesCat. No.: HY-W344175CAS No.: 72338-49-9
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1-(2-Hydroxyethyl)piperidine-4-carbonitrile
0 ImagesCat. No.: HY-W102596CAS No.: 21168-73-0
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1-Piperazinehexanoic acid
0 ImagesCat. No.: HY-162736CAS No.: 17096-76-31-Piperazinehexanoic acid is a PROTAC linker that serve as a key intermediate for the synthesis of complete JMV7048 (HY-162704).
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1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine
0 ImagesCat. No.: HY-W118459CAS No.: 1245505-23-0
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Ethyl 3-(4-formylphenyl)propanoate
0 ImagesCat. No.: HY-W553425CAS No.: 445483-72-7
![4-(Benzyloxycarbonylamino)bicyclo[2.2.2]octane-1-carboxylic acid](https://file.medchemexpress.com/product_pic/hy-w059218.gif "Click to View 4-(Benzyloxycarbonylamino)bicyclo[2.2.2]octane-1-carboxylic acid Product Detail")
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(S)-Boc-NH-Cy-C-NH2 hydrochloride
0 ImagesCat. No.: HY-W538924CAS No.: 2415751-53-8
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1,10-Decanedithiol
0 ImagesCat. No.: HY-W276070CAS No.: 1191-67-9
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Tert-butyl N-[3-(methylaminomethyl)cyclobutyl]carbamate
![Tert-butyl N-[3-(methylaminomethyl)cyclobutyl]carbamate](https://file.medchemexpress.com/product_pic/hy-w675919.gif "Click to View Tert-butyl N-[3-(methylaminomethyl)cyclobutyl]carbamate Product Detail")
0 ImagesCat. No.: HY-W675919CAS No.: 2285247-39-2
![tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate hydrochloride](https://file.medchemexpress.com/product_pic/hy-30590.gif "Click to View tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate hydrochloride Product Detail")
